A recent study highlights the crucial role of metabolism and immune responses in atherosclerosis, challenging the traditional focus on lipids and LDL.
Key Findings:
Immune cell metabolic reprogramming orchestrates inflammatory processes within arterial walls.
Metabolic pathways such as glycolysis and TCA cycle are pivotal in regulating immune responses.
Metabolites significantly influence atherosclerosis, making them promising therapeutic targets.
Implications:
Macrophages and T cells undergo dynamic metabolic changes, impacting plaque progression and stability.
The interplay between metabolism and immunity opens new avenues for preventive and therapeutic strategies.
Rethinking Atherosclerosis:
Beyond lipids: Understanding metabolic control of immune responses is key to tackling this chronic inflammatory disease.
Certo, M., M. Rahimzadeh, and C. Mauro, Immunometabolism in atherosclerosis: a new understanding of an old disease. Trends in Biochemical Sciences, 2024.
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