Our immune response isn't just about fighting off invaders. It’s also about healing and maintaining balance! Here are the key Insights from Recent Research on Eosinophilic Gastrointestinal Diseases (EGIDs):
Regulatory T Cells (Tregs) are crucial in controlling immune responses, not just inducing inflammation. These cells are vital for keeping our immune system in check by producing anti-inflammatory signals like IL-10 and TGF-β.
Eosinophils, traditionally seen as harmful due to their cytotoxic capabilities, also have regulatory functions. They can inhibit the differentiation of other pro-inflammatory cells, highlighting their dual role in defense and repair.
Cytokine and Chemokine Balance: EGIDs patients show an increase in both pro-inflammatory (IL-4, IL-5, IL-13, IL-17) and anti-inflammatory (TGF-β, IL-10) cytokines, showcasing the immune system's effort to balance between attacking threats and promoting healing.
Treg Plasticity: In inflammatory conditions, Tregs can lose their regulatory function and turn into pro-inflammatory cells, demonstrating the dynamic nature of our immune responses.
Our immune system is a master of balance, always striving to defend against threats while also repairing and maintaining harmony within our bodies. This challenges the traditional view that it leans more toward inflammation. Instead, it highlights the intricate dance between pro-inflammatory and anti-inflammatory responses, ensuring our overall well-being.
Kheshtchin N, Kanannejad Z, Ghahramani Z, Esmaeilzadeh H, Sepahi N. Balancing immune responses: regulatory cells in eosinophilic gastrointestinal disorders. Frontiers in immunology. 2024;15.
#Immunology #Health #ScienceFacts #EosinophilicDiseases #Healing #Balance #ImmuneSystem #Inflammation #Research
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