Micro- and nano-plastics (MNPs) can wreak havoc on our bodies at the molecular level. Here's how they cause oxidative stress and inflammation:
Protein Corona Formation: MNPs interact with proteins in our body, forming a "protein corona" that changes their identity and increases persistence. This can disrupt normal cellular functions.
Entry Routes:
Infusion: When MNPs enter the bloodstream, they travel to various organs, causing cytotoxicity and genotoxicity.
Inhalation: Inhaled MNPs accumulate in the lungs, leading to inflammation and impaired lung function.
Dermal Contact: MNPs from cosmetics or topical medications penetrate the skin, causing inflammation and allergic reactions.
Disrupting Metabolic Pathways: MNPs can hyperactivate or deactivate crucial enzymes, leading to oxidative stress, where harmful free radicals overwhelm the body's defenses.
Inflammation: The disruption caused by MNPs triggers inflammation, a key factor in many chronic diseases.
Organ Toxicity: MNPs can accumulate in the liver, brain, lungs, heart, and GI tract, leading to significant health issues.
Reproductive Risks: MNPs can transfer from mother to fetus through the placenta, posing risks to fetal development.
Call to Action: More research is needed to fully understand the long-term effects of MNP exposure, especially from pharmaceuticals and medical devices. Stay informed and advocate for cleaner, safer environments!
Gopinath PM, Parvathi VD, Yoghalakshmi N, Kumar SM, Athulya PA, Mukherjee A, et al. Plastic particles in medicine: A systematic review of exposure and effects to human health. Chemosphere. 2022;303(Pt 3):135227.
#HealthAlert #MicroPlastics #NanoPlastics #OxidativeStress #Inflammation #EnvironmentalHealth #PublicHealth
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