Mitochondrial dysfunction contributes to the progression of diabetic kidney disease (DKD) by disrupting energy production, altering metabolism, and driving inflammation.
Here’s how:
Energy Disruption: Mitochondria produce ATP, the energy kidney cells need to function. In DKD, mitochondrial dysfunction leads to reduced ATP, impairing kidney function.
Metabolic Changes: Mitochondria play a key role in metabolic pathways like the TCA cycle and oxidative phosphorylation (OXPHOS). Dysfunction in these processes creates energy deficits that contribute to kidney damage.
Oxidative Stress: Damaged mitochondria produce reactive oxygen species (ROS), causing oxidative stress that worsens kidney injury.
Inflammation: Mitochondrial dysfunction also creates an inflammatory environment, attracting immune cells that exacerbate kidney damage. This link between metabolism and immune function is reshaping our understanding of DKD.
Therapeutic Insights: Targeting mitochondrial health through lifestyle changes, like exercise and weight control, and emerging therapies may slow DKD progression and protect kidney function.
Understanding the role of mitochondria opens new avenues for therapies in DKD.
Narongkiatikhun, P., Choi, Y. J., Hampson, H., Gotzamanis, J., Zhang, G., van Raalte, D. H., Saulnier, P. J. (2024). Unraveling Diabetic Kidney Disease: The Roles of Mitochondrial Dysfunction and Immunometabolism. Kidney International Reports. https://doi.org/https://doi.org/10.1016/j.ekir.2024.09.019
#DKD #Diabetes #Mitochondria #KidneyHealth #OxidativeStress #Immunometabolism #HealthScience #MedicalResearch #ChronicDisease
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